Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Built him out of meat cubes.
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked Challenge #8.
Isaac now holds the D6!
Unlocked even more bosses!
Unlocked Challenge #4.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Unlocked new bosses!
You became Lord of the Flies.
New mode unlocked!
Unlocked Challenge #11.
Unlocked Challenge #19.
You are the best!!
They are waiting.
Unlocked new enemies!
Alt stage to the womb.
Beat caves without taking damage.
Beat depths without taking damage.
Alt stage to the depths.
Donated 600 pennies to the shop.
New boss in the basement!
Beat basement without taking damage.
Beat womb without taking damage.
Alt stage to the caves.
New boss in the caves!
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked another miniboss!
Unlocked Challenge #9.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with the Forgotten.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Samson.
Complete the Corpse with Cain.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Lilith.
Complete the Corpse with Eden.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Lazarus.
Complete the Corpse with Keeper.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Azazel.
Obtain 99 pennies. Then spend every single one of them.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Make a new friend!
Complete the final chapter with Isaac.
The other side is calling...
Kill 10 Battery Bums.
Beat the game in Hard mode with Jacob and Esau.
Beat Greedier mode with Bethany.
You are just like your father...
Complete the Corpse with Judas.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Enter the Corpse...
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in Downpour.
Defeat all bosses in the Mines.
Get that song out of her head.
Complete ??? 3 times.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete the Cathedral with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.