Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked Challenge #8.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #4.
New boss in the womb!
Unlocked new bosses!
New mode unlocked!
Donated 600 pennies to the shop.
Unlocked a new character.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Unlocked Challenge #11.
You are the best!!
Unlocked new enemies!
Alt stage to the womb.
Beat caves without taking damage.
They are waiting.
Alt stage to the depths.
Built him out of meat cubes.
Alt stage to the caves.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Beat womb without taking damage.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
New boss in the depths!
The game just got harder!
Unlocked a new boss!
Donated 100 pennies to the shop.
Beat basement without taking damage.
New boss in the caves!
Unlocked Challenge #6.
Unlocked another miniboss!
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #29.
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Make a new friend!
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
Kill 10 Battery Bums.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Beat the Void with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Get that song out of her head.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.
Spend 40+ pennies in a single shop.
Kids shouldn't believe in fortunes...