Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked Challenge #11.
New mode unlocked!
Beat caves without taking damage.
Donated 600 pennies to the shop.
Unlocked a new character.
Unlocked even more bosses!
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked new bosses!
Unlocked Challenge #4.
You are the best!!
Beat depths without taking damage.
Donated 200 pennies to the shop.
Isaac now holds the D6!
Alt stage to the womb.
Beat womb without taking damage.
They are waiting.
Unlocked new enemies!
You became Lord of the Flies.
Alt stage to the depths.
Built him out of meat cubes.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
Alt stage to the caves.
New boss in the caves!
New boss in the depths!
New boss in the basement!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Unlocked Challenge #9.
The game just got harder!
Unlocked Challenge #6.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Beat basement without taking damage.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Nerd x 1000000
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Get that song out of her head.
Beat everything in Hard Mode as every character.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with ???.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Corpse with the Forgotten.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Keeper.
They will charge you up... for a small fee.
Complete the Corpse with Eve.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Judas.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Eden.
Complete the final chapter with Judas.
Complete the Corpse with Magdalene.
Complete the final chapter with ???.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Complete the final chapter with the Lost.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the final chapter with Magdalene.
The other side is calling...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete the Chest with Bethany.
Beat the Void with Bethany.
Complete the Cathedral with Bethany.
Kill 10 Battery Bums.
Obtain 99 pennies. Then spend every single one of them.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Make a new friend!
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.