Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #11.
Isaac now holds the D6!
Donated 200 pennies to the shop.
Unlocked new bosses!
New boss in the womb!
You are the best!!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
New mode unlocked!
Unlocked a new character.
Alt stage to the womb.
Unlocked Challenge #19.
Alt stage to the depths.
Donated 100 pennies to the shop.
They are waiting.
Unlocked new enemies!
Alt stage to the caves.
New boss in the caves!
New boss in the basement!
Donated 20 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Your future's past waits.
Unlocked a new boss!
Unlocked Challenge #9.
New boss in the depths!
The game just got harder!
Beat basement without taking damage.
Unlocked Challenge #6.
Built him out of meat cubes.
Unlocked Challenge #5.
Unlocked Challenge #10.
You became Lord of the Flies.
Unlocked another miniboss!
Unlocked Challenge #8.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
They will charge you up... for a small fee.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Judas.
Complete the Corpse with the Lost.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Get that song out of her head.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Complete the Dark Room with Bethany.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Kill 10 Battery Bums.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Complete the final chapter with the Forgotten.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with the Forgotten.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Defeat Baby Plum 10 times.
Complete ??? 3 times.
Spend 40+ pennies in a single shop.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life