Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked a new character.
Unlocked even more bosses!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #8.
Unlocked Challenge #4.
Beat depths without taking damage.
Unlocked new bosses!
New boss in the womb!
New mode unlocked!
Unlocked Challenge #19.
Alt stage to the womb.
You are the best!!
Unlocked new enemies!
Donated 600 pennies to the shop.
They are waiting.
New boss in the basement!
Alt stage to the depths.
New boss in the caves!
You became Lord of the Flies.
Alt stage to the caves.
New boss in the depths!
Unlocked another miniboss!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #9.
Beat womb without taking damage.
Unlocked a new boss!
Donated 200 pennies to the shop.
Beat caves without taking damage.
The game just got harder!
Built him out of meat cubes.
Unlocked Challenge #6.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Nerd x 1000000
Unlocked a secret.
Unlocked Challenge #26.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Keeper.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with Bethany.
Complete the final chapter with Jacob and Esau.
Kill Hornfel before he escapes!
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Make a new friend!
Complete the final chapter with Keeper.
Complete the Corpse with Eden.
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the Corpse with Apollyon.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Samson.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the Corpse with Judas.
Complete the Corpse with Bethany.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Lilith.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
Complete the Corpse with Azazel.
Get that song out of her head.
Defeat all bosses in the Mines.
Complete the final chapter with Apollyon.
Complete the Corpse with Cain.
Defeat all bosses in the Mausoleum.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Kids shouldn't believe in fortunes...
Complete the final chapter with the Forgotten.
Complete the final chapter with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Defeat Baby Plum 10 times.
Complete ??? 3 times.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life