Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked a new character.
New boss in the womb!
Unlocked new bosses!
Built him out of meat cubes.
New mode unlocked!
Unlocked Challenge #11.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
You are the best!!
Alt stage to the womb.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Beat womb without taking damage.
Beat depths without taking damage.
Alt stage to the depths.
They are waiting.
Unlocked new enemies!
Unlocked a new boss!
Alt stage to the caves.
New boss in the caves!
New boss in the basement!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Donated 200 pennies to the shop.
Unlocked Challenge #9.
Beat caves without taking damage.
The game just got harder!
Unlocked Challenge #6.
Donated 100 pennies to the shop.
You became Lord of the Flies.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Unlocked Challenge #8.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #23.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Make a new friend!
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Kill 10 Battery Bums.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the final chapter with Magdalene.
Complete the final chapter with Judas.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
The other side is calling...
Beat Greedier mode with Bethany.
Beat Greed mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
You are just like your father...
Where could it lead to?
Complete the Corpse with Judas.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Get that song out of her head.
Complete ??? 3 times.
Beat Hard mode as Lazarus without losing a life