Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
10 or more kills using a single Bio-Bomb.
Destroy 5 helicopters using Pack Leader.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Complete the game.
Counter enemy attacks 20 times using Shield.
Complete LABOR OF LOVE.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete all //BLACKNET dossiers.
Find all BlackBoxes.
Destroy all Lairs.
Defeat all Field Ops teams.
Acquire all 46 upgrades through Consumes.
Reach the highest point in the world.
Simultaneously kill 2 Brawlers using a single Devastator.
Mount a helicopter using Whipfist.
Acquire 30 upgrades through Consumes.
Complete FALL FROM GRACE.
Acquire a Mutation in each of the 5 categories.
Consume 10 //BLACKNET targets.
Stealth hijack 5 tanks or APCs.
Deflect 5 missiles at enemies using Shield Block.
20 or more kills with a single Hammerfist dive attack.
Destroy a single Lair.
Destroy 5 vehicles using a Finisher.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Weaponize 10 vehicles.
Destroy a Strike Team in 15 seconds or less.
Acquire 5 Mutations.
10 or more kills with a single Black Hole attack.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Karate kick a helicopter.
Complete RESURRECTION.
Complete MEET YOUR MAKER.