Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy a Strike Team in 15 seconds or less.
Complete the game.
Acquire all 46 upgrades through Consumes.
Destroy 5 helicopters using Pack Leader.
Destroy 5 vehicles using a Finisher.
20 or more kills with a single Hammerfist dive attack.
Defeat all Field Ops teams.
Destroy all Lairs.
Find all BlackBoxes.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Weaponize 10 vehicles.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Deflect 5 missiles at enemies using Shield Block.
Mount a helicopter using Whipfist.
Complete FALL FROM GRACE.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
10 or more kills with a single Black Hole attack.
Acquire 5 Mutations.
Stealth Consume 50 Blackwatch troopers.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Trigger 50 alerts.
5 consumes in 10 seconds or less.
Dismember a Brawler.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.