Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Complete the game.
Acquire all 46 upgrades through Consumes.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy a Strike Team in 15 seconds or less.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Simultaneously kill 2 Brawlers using a single Devastator.
20 or more kills with a single Hammerfist dive attack.
10 or more kills with a single Black Hole attack.
10 or more kills using a single Bio-Bomb.
Find all BlackBoxes.
Destroy all Lairs.
Reach the highest point in the world.
Defeat all Field Ops teams.
Acquire 30 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Complete FALL FROM GRACE.
Karate kick a helicopter.
Stealth hijack 5 tanks or APCs.
Destroy 5 vehicles using a Finisher.
Counter enemy attacks 20 times using Shield.
Weaponize 10 vehicles.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
Complete NATURAL SELECTION.
5 consumes in 10 seconds or less.
Stealth Consume 50 Blackwatch troopers.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Acquire 5 Mutations.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.