Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Complete the game on HARD difficulty.
Fully upgrade Heller.
Stealth hijack 5 tanks or APCs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 helicopters using Pack Leader.
Acquire all 46 upgrades through Consumes.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy all Lairs.
Complete the game.
Complete LABOR OF LOVE.
Destroy a Strike Team in 15 seconds or less.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
20 or more kills with a single Hammerfist dive attack.
Complete all //BLACKNET dossiers.
10 or more kills using a single Bio-Bomb.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Weaponize 10 vehicles.
10 or more kills with a single Black Hole attack.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Complete FALL FROM GRACE.
Stealth Consume 50 Blackwatch troopers.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Simultaneously kill 2 Brawlers using a single Devastator.
Trigger 50 alerts.
Karate kick a helicopter.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
5 consumes in 10 seconds or less.
Complete MEET YOUR MAKER.