Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Counter enemy attacks 20 times using Shield.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 helicopters using Pack Leader.
Destroy 5 vehicles using a Finisher.
10 or more kills with a single Black Hole attack.
Mount a helicopter using Whipfist.
Weaponize 10 vehicles.
10 or more kills using a single Bio-Bomb.
Karate kick a helicopter.
Deflect 5 missiles at enemies using Shield Block.
Destroy a Strike Team in 15 seconds or less.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Find all BlackBoxes.
Defeat all Field Ops teams.
Reach the highest point in the world.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
5 consumes in 10 seconds or less.
Complete NATURAL SELECTION.
Acquire 5 Mutations.
Stealth Consume 50 Blackwatch troopers.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.