Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game.
Complete the game on HARD difficulty.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Acquire 30 upgrades through Consumes.
Find all BlackBoxes.
Destroy all Lairs.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Defeat all Field Ops teams.
10 or more kills using a single Bio-Bomb.
Reach the highest point in the world.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete FALL FROM GRACE.
Destroy 5 helicopters using Pack Leader.
Destroy 5 vehicles using a Finisher.
Consume 10 //BLACKNET targets.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
20 or more kills with a single Hammerfist dive attack.
Acquire a Mutation in each of the 5 categories.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
10 or more kills with a single Black Hole attack.
Complete NATURAL SELECTION.
Weaponize 10 vehicles.
Counter enemy attacks 20 times using Shield.
5 consumes in 10 seconds or less.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Acquire 5 Mutations.
Destroy a Strike Team in 15 seconds or less.
Karate kick a helicopter.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.