Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Destroy 5 vehicles using a Finisher.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy 5 helicopters using Pack Leader.
Simultaneously kill 2 Brawlers using a single Devastator.
Complete the game.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Karate kick a helicopter.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Complete FALL FROM GRACE.
10 or more kills using a single Bio-Bomb.
Consume 10 //BLACKNET targets.
Stealth hijack 5 tanks or APCs.
Acquire a Mutation in each of the 5 categories.
10 or more kills with a single Black Hole attack.
Weaponize 10 vehicles.
Destroy a Strike Team in 15 seconds or less.
20 or more kills with a single Hammerfist dive attack.
Destroy a single Lair.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Dismember a Brawler.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.