Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Acquire all 46 upgrades through Consumes.
Fully upgrade Heller.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Acquire 30 upgrades through Consumes.
Destroy a Strike Team in 15 seconds or less.
Destroy 5 helicopters using Pack Leader.
Weaponize 10 vehicles.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Defeat all Field Ops teams.
Find all BlackBoxes.
10 or more kills using a single Bio-Bomb.
Destroy all Lairs.
Destroy 5 vehicles using a Finisher.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Stealth Consume 50 Blackwatch troopers.
Deflect 5 missiles at enemies using Shield Block.
10 or more kills with a single Black Hole attack.
Trigger 50 alerts.
Karate kick a helicopter.
Acquire 5 Mutations.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.