Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Complete the game.
Complete the game on HARD difficulty.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Destroy 5 helicopters using Pack Leader.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Find all BlackBoxes.
Destroy all Lairs.
Defeat all Field Ops teams.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
10 or more kills with a single Black Hole attack.
Simultaneously kill 2 Brawlers using a single Devastator.
Stealth Consume 50 Blackwatch troopers.
Consume 10 //BLACKNET targets.
Destroy 5 vehicles using a Finisher.
Stealth hijack 5 tanks or APCs.
Acquire a Mutation in each of the 5 categories.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy a single Lair.
Destroy a Strike Team in 15 seconds or less.
Acquire 10 upgrades through Consumes.
Weaponize 10 vehicles.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Acquire 5 Mutations.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
5 consumes in 10 seconds or less.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.