Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
10 or more kills with a single Black Hole attack.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Weaponize 10 vehicles.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Simultaneously kill 2 Brawlers using a single Devastator.
10 or more kills using a single Bio-Bomb.
Complete the game.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Complete LABOR OF LOVE.
Destroy a Strike Team in 15 seconds or less.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Karate kick a helicopter.
Destroy 5 helicopters using Pack Leader.
Complete all //BLACKNET dossiers.
Defeat all Field Ops teams.
Find all BlackBoxes.
Acquire 30 upgrades through Consumes.
Destroy all Lairs.
Complete FALL FROM GRACE.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
5 consumes in 10 seconds or less.
20 or more kills with a single Hammerfist dive attack.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Acquire 5 Mutations.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.