Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Defeat all Field Ops teams.
Destroy 5 helicopters using Pack Leader.
Find all BlackBoxes.
Destroy all Lairs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Mount a helicopter using Whipfist.
10 or more kills using a single Bio-Bomb.
10 or more kills with a single Black Hole attack.
Complete all //BLACKNET dossiers.
Simultaneously kill 2 Brawlers using a single Devastator.
Weaponize 10 vehicles.
Acquire all 46 upgrades through Consumes.
Complete the game.
Complete LABOR OF LOVE.
Destroy 5 vehicles using a Finisher.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Complete FALL FROM GRACE.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
20 or more kills with a single Hammerfist dive attack.
Destroy a Strike Team in 15 seconds or less.
5 consumes in 10 seconds or less.
Destroy a single Lair.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Karate kick a helicopter.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.