Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
10 or more kills using a single Bio-Bomb.
Acquire all 46 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy 5 helicopters using Pack Leader.
Complete the game.
Complete the game on HARD difficulty.
Complete LABOR OF LOVE.
20 or more kills with a single Hammerfist dive attack.
Mount a helicopter using Whipfist.
Complete all //BLACKNET dossiers.
Destroy 5 vehicles using a Finisher.
Stealth hijack 5 tanks or APCs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Complete FALL FROM GRACE.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy a Strike Team in 15 seconds or less.
Weaponize 10 vehicles.
Consume 10 //BLACKNET targets.
Counter enemy attacks 20 times using Shield.
10 or more kills with a single Black Hole attack.
5 consumes in 10 seconds or less.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Acquire 5 Mutations.
Destroy a single Lair.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Trigger 50 alerts.
Dismember a Brawler.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.