Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Defeat all Field Ops teams.
Destroy all Lairs.
Find all BlackBoxes.
Acquire 30 upgrades through Consumes.
Destroy 5 vehicles using a Finisher.
Destroy a Strike Team in 15 seconds or less.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy 5 helicopters using Pack Leader.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
10 or more kills using a single Bio-Bomb.
Complete FALL FROM GRACE.
Deflect 5 missiles at enemies using Shield Block.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
20 or more kills with a single Hammerfist dive attack.
Counter enemy attacks 20 times using Shield.
Destroy a single Lair.
Stealth hijack 5 tanks or APCs.
Acquire 10 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Complete NATURAL SELECTION.
Weaponize 10 vehicles.
Karate kick a helicopter.
Acquire 5 Mutations.
Stealth Consume 50 Blackwatch troopers.
Trigger 50 alerts.
10 or more kills with a single Black Hole attack.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.