Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game.
Complete the game on HARD difficulty.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Weaponize 10 vehicles.
Acquire 30 upgrades through Consumes.
Complete FALL FROM GRACE.
Stealth hijack 5 tanks or APCs.
Simultaneously kill 2 Brawlers using a single Devastator.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Counter enemy attacks 20 times using Shield.
5 consumes in 10 seconds or less.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
10 or more kills with a single Black Hole attack.
Trigger 50 alerts.
Complete MEET YOUR MAKER.
Complete RESURRECTION.
Meet Father Guerra.
Acquire a Prototype Power.
Complete a //BLACKNET operation.
Dismember a Brawler.
Karate kick a helicopter.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy a Strike Team in 15 seconds or less.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Reach the highest point in the world.
Destroy all Lairs.
Fully upgrade Heller.