Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Fully upgrade Heller.
Complete all //BLACKNET dossiers.
10 or more kills with a single Black Hole attack.
Mount a helicopter using Whipfist.
Counter enemy attacks 20 times using Shield.
Destroy 5 vehicles using a Finisher.
Destroy 5 helicopters using Pack Leader.
Destroy a Strike Team in 15 seconds or less.
Weaponize 10 vehicles.
10 or more kills using a single Bio-Bomb.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Destroy all Lairs.
Deflect 5 missiles at enemies using Shield Block.
Acquire 30 upgrades through Consumes.
Simultaneously kill 2 Brawlers using a single Devastator.
Find all BlackBoxes.
Defeat all Field Ops teams.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
Complete NATURAL SELECTION.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
Acquire 5 Mutations.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Karate kick a helicopter.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.