Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Destroy a Strike Team in 15 seconds or less.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy all Lairs.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 vehicles using a Finisher.
10 or more kills using a single Bio-Bomb.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Simultaneously kill 2 Brawlers using a single Devastator.
10 or more kills with a single Black Hole attack.
20 or more kills with a single Hammerfist dive attack.
Karate kick a helicopter.
Consume 10 //BLACKNET targets.
Complete FALL FROM GRACE.
Stealth Consume 50 Blackwatch troopers.
Acquire 10 upgrades through Consumes.
Deflect 5 missiles at enemies using Shield Block.
Weaponize 10 vehicles.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Acquire 5 Mutations.
Trigger 50 alerts.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.