Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Simultaneously kill 2 Brawlers using a single Devastator.
20 or more kills with a single Hammerfist dive attack.
Complete FALL FROM GRACE.
10 or more kills with a single Black Hole attack.
Destroy 5 vehicles using a Finisher.
Acquire a Mutation in each of the 5 categories.
Consume 10 //BLACKNET targets.
Karate kick a helicopter.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Acquire 5 Mutations.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
5 consumes in 10 seconds or less.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.
Destroy a Strike Team in 15 seconds or less.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 helicopters using Pack Leader.
Weaponize 10 vehicles.
Mount a helicopter using Whipfist.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Reach the highest point in the world.
Fully upgrade Heller.