Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire 30 upgrades through Consumes.
Complete FALL FROM GRACE.
Stealth Consume 50 Blackwatch troopers.
Acquire a Mutation in each of the 5 categories.
Consume 10 //BLACKNET targets.
Destroy a single Lair.
5 consumes in 10 seconds or less.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy a Strike Team in 15 seconds or less.
10 or more kills with a single Black Hole attack.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Destroy 5 helicopters using Pack Leader.
Weaponize 10 vehicles.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Reach the highest point in the world.
Destroy all Lairs.
Fully upgrade Heller.
Complete the game on HARD difficulty.