Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 helicopters using Pack Leader.
10 or more kills using a single Bio-Bomb.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
20 or more kills with a single Hammerfist dive attack.
10 or more kills with a single Black Hole attack.
Complete the game.
Complete the game on HARD difficulty.
Complete all //BLACKNET dossiers.
Complete LABOR OF LOVE.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy a Strike Team in 15 seconds or less.
Reach the highest point in the world.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Defeat all Field Ops teams.
Karate kick a helicopter.
Complete FALL FROM GRACE.
Weaponize 10 vehicles.
Consume 10 //BLACKNET targets.
Stealth hijack 5 tanks or APCs.
Acquire a Mutation in each of the 5 categories.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Acquire 5 Mutations.
Trigger 50 alerts.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Complete a //BLACKNET operation.
5 consumes in 10 seconds or less.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.