Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Destroy all Lairs.
Defeat all Field Ops teams.
Find all BlackBoxes.
Acquire 30 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Complete FALL FROM GRACE.
Destroy 5 helicopters using Pack Leader.
10 or more kills using a single Bio-Bomb.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
20 or more kills with a single Hammerfist dive attack.
Weaponize 10 vehicles.
Destroy 5 vehicles using a Finisher.
Destroy a Strike Team in 15 seconds or less.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
10 or more kills with a single Black Hole attack.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Simultaneously kill 2 Brawlers using a single Devastator.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Karate kick a helicopter.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Acquire 5 Mutations.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.