Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Destroy all Lairs.
Find all BlackBoxes.
Defeat all Field Ops teams.
Acquire 30 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
10 or more kills using a single Bio-Bomb.
Complete FALL FROM GRACE.
Destroy 5 helicopters using Pack Leader.
20 or more kills with a single Hammerfist dive attack.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 vehicles using a Finisher.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy a Strike Team in 15 seconds or less.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Stealth hijack 5 tanks or APCs.
Complete NATURAL SELECTION.
Weaponize 10 vehicles.
Simultaneously kill 2 Brawlers using a single Devastator.
Counter enemy attacks 20 times using Shield.
Stealth Consume 50 Blackwatch troopers.
Acquire 5 Mutations.
Trigger 50 alerts.
Deflect 5 missiles at enemies using Shield Block.
10 or more kills with a single Black Hole attack.
Dismember a Brawler.
Complete a //BLACKNET operation.
5 consumes in 10 seconds or less.
Acquire a Prototype Power.
Meet Father Guerra.
Karate kick a helicopter.
Complete RESURRECTION.
Complete MEET YOUR MAKER.