Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
10 or more kills using a single Bio-Bomb.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Acquire 30 upgrades through Consumes.
Defeat all Field Ops teams.
Destroy all Lairs.
Find all BlackBoxes.
Reach the highest point in the world.
Complete FALL FROM GRACE.
Weaponize 10 vehicles.
Destroy 5 vehicles using a Finisher.
Consume 10 //BLACKNET targets.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Acquire 5 Mutations.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.
Destroy a Strike Team in 15 seconds or less.
10 or more kills with a single Black Hole attack.
Simultaneously kill 2 Brawlers using a single Devastator.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
20 or more kills with a single Hammerfist dive attack.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Fully upgrade Heller.
Complete the game on HARD difficulty.