Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Weaponize 10 vehicles.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy 5 helicopters using Pack Leader.
Acquire 30 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Complete FALL FROM GRACE.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire a Mutation in each of the 5 categories.
Consume 10 //BLACKNET targets.
Destroy a single Lair.
Acquire 5 Mutations.
Stealth hijack 5 tanks or APCs.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Deflect 5 missiles at enemies using Shield Block.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Trigger 50 alerts.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy a Strike Team in 15 seconds or less.
10 or more kills with a single Black Hole attack.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Destroy 5 vehicles using a Finisher.
Acquire all 46 upgrades through Consumes.
Destroy all Lairs.
Fully upgrade Heller.