Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Complete all //BLACKNET dossiers.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
10 or more kills using a single Bio-Bomb.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Destroy 5 vehicles using a Finisher.
Destroy all Lairs.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Find all BlackBoxes.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire 30 upgrades through Consumes.
20 or more kills with a single Hammerfist dive attack.
Defeat all Field Ops teams.
Counter enemy attacks 20 times using Shield.
Destroy a Strike Team in 15 seconds or less.
Reach the highest point in the world.
Complete FALL FROM GRACE.
Stealth hijack 5 tanks or APCs.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Weaponize 10 vehicles.
Destroy a single Lair.
10 or more kills with a single Black Hole attack.
5 consumes in 10 seconds or less.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Trigger 50 alerts.
Acquire 5 Mutations.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.