Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Destroy 5 vehicles using a Finisher.
20 or more kills with a single Hammerfist dive attack.
Mount a helicopter using Whipfist.
Destroy 5 helicopters using Pack Leader.
10 or more kills using a single Bio-Bomb.
Karate kick a helicopter.
Complete the game on HARD difficulty.
Complete the game.
Complete all //BLACKNET dossiers.
Complete LABOR OF LOVE.
Weaponize 10 vehicles.
Acquire 30 upgrades through Consumes.
Simultaneously kill 2 Brawlers using a single Devastator.
Reach the highest point in the world.
Complete FALL FROM GRACE.
Consume 10 //BLACKNET targets.
10 or more kills with a single Black Hole attack.
Acquire a Mutation in each of the 5 categories.
Acquire 10 upgrades through Consumes.
Destroy a single Lair.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Stealth Consume 50 Blackwatch troopers.
Deflect 5 missiles at enemies using Shield Block.
Acquire 5 Mutations.
Destroy a Strike Team in 15 seconds or less.
5 consumes in 10 seconds or less.
Trigger 50 alerts.
Dismember a Brawler.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.