Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Acquire all 46 upgrades through Consumes.
Fully upgrade Heller.
Complete the game.
Complete LABOR OF LOVE.
Destroy 5 helicopters using Pack Leader.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Complete all //BLACKNET dossiers.
Acquire 30 upgrades through Consumes.
Mount a helicopter using Whipfist.
Find all BlackBoxes.
Destroy all Lairs.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Defeat all Field Ops teams.
Destroy 5 vehicles using a Finisher.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Weaponize 10 vehicles.
Simultaneously kill 2 Brawlers using a single Devastator.
Stealth Consume 50 Blackwatch troopers.
Consume 10 //BLACKNET targets.
Counter enemy attacks 20 times using Shield.
Acquire 10 upgrades through Consumes.
Acquire a Mutation in each of the 5 categories.
Destroy a Strike Team in 15 seconds or less.
Deflect 5 missiles at enemies using Shield Block.
Destroy a single Lair.
Complete NATURAL SELECTION.
Trigger 50 alerts.
10 or more kills with a single Black Hole attack.
5 consumes in 10 seconds or less.
Karate kick a helicopter.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Acquire 5 Mutations.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.