Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game.
Complete the game on HARD difficulty.
Acquire all 46 upgrades through Consumes.
Complete LABOR OF LOVE.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Destroy 5 vehicles using a Finisher.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
10 or more kills with a single Black Hole attack.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Destroy 5 helicopters using Pack Leader.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy a Strike Team in 15 seconds or less.
Stealth hijack 5 tanks or APCs.
Karate kick a helicopter.
Complete FALL FROM GRACE.
Simultaneously kill 2 Brawlers using a single Devastator.
Weaponize 10 vehicles.
Consume 10 //BLACKNET targets.
20 or more kills with a single Hammerfist dive attack.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
5 consumes in 10 seconds or less.
Counter enemy attacks 20 times using Shield.
Trigger 50 alerts.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
Acquire 5 Mutations.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.