Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Mount a helicopter using Whipfist.
Acquire all 46 upgrades through Consumes.
Counter enemy attacks 20 times using Shield.
Weaponize 10 vehicles.
Destroy 5 helicopters using Pack Leader.
10 or more kills using a single Bio-Bomb.
20 or more kills with a single Hammerfist dive attack.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Deflect 5 missiles at enemies using Shield Block.
10 or more kills with a single Black Hole attack.
Destroy a Strike Team in 15 seconds or less.
Complete the game.
Complete LABOR OF LOVE.
Destroy 5 vehicles using a Finisher.
Complete all //BLACKNET dossiers.
Reach the highest point in the world.
Destroy all Lairs.
Find all BlackBoxes.
Acquire 30 upgrades through Consumes.
Defeat all Field Ops teams.
Karate kick a helicopter.
Stealth Consume 50 Blackwatch troopers.
Complete FALL FROM GRACE.
Simultaneously kill 2 Brawlers using a single Devastator.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
5 consumes in 10 seconds or less.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Acquire 5 Mutations.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.