- Practitioner
Complete Chapter 1 on any difficulty.
- Operative
Complete Chapter 2 on any difficulty.
- Specialist
Complete Chapter 3 on any difficulty.
- Master
Complete Chapter 4 on any difficulty.
- Conjurer
Kill 100 Enemies while using the Dragon's Grasp.
- Draconist
Kill 400 Enemies while using the Dragon's Grasp.
- Gunner
Kill 100 Enemies while using the Minigun.
- Heavy Operator
Kill 400 Enemies while using the Minigun.
- Breaker
Kill 100 Enemies while using the Hailstorm.
- Freezer
Kill 400 Enemies while using the Hailstorm.
- Shocker
Kill 100 Enemies while using Shock Therapy.
- Stormer
Kill 400 Enemies while using Shock Therapy.
- Lighter
Kill 100 Enemies while using the Sunbeam.
- Paladin
Kill 400 Enemies while using the Sunbeam.
- Bomber
Kill 100 Enemies while using the Dream Cleaner.
- Technician
Kill 400 Enemies while using the Dream Cleaner.
- Absolute Threshold
Achieve the Gold weapon upgrade rank on the Insanity difficulty.
- Dissociative Disorder
Kill 25 Enemies while teleporting.
- Manic Episode
Enter Berserker Rage at least once in each level of the game in Story mode.
- Aversion Therapy
Complete a level on any difficulty without dying.
- Immortal
Complete every level on any difficulty without dying.
- Hallucinations
Die 5 times while in the Subconscious.
- OCD
Use every weapon at least once in any level of the game in Story mode.
- Latent Abilities
Complete every level on any difficulty without dying in the Subconscious.
- Opiophobia
Complete one level without receiving any Health pickups.
- Wisdom
Find and enter in all of the Secret areas in any one level of the game.
- Poor Sleeper
Complete Story mode on the Bad Dream difficulty.
- Somnambulist
Complete Story mode on the Nightmare difficulty.
- Lucid Guardian
Complete Story mode on the Insanity difficulty.
- Rhabdophobia
Complete one level in Story mode while only using the Dragon's Grasp.
- Hoplophobia
Complete one level in Story mode while only using the Minigun.
- Pagophobia
Complete one level in Story mode while only using the Hailstorm.
- Astraphobia
Complete one level in Story mode while only using Shock Therapy.
- Heliophobia
Complete one level in Story mode while only using the Sunbeam.
- Ligyrophobia
Complete one level in Story mode while only using the Dream Cleaner.
- Psychoanalysis
Kill 25 opponents in any Multiplayer game mode.
- Prescription
Kill 100 opponents in any Multiplayer game mode.
- Treatment
Kill 300 opponents in any Multiplayer game mode.
- Instinctual Action
Enter Berserker Rage during a Multiplayer game.
- Untouchable
Kill 10 opponents in a row without dying in a Multiplayer game.
- Free Association
Kill 3 or more opponents at the same time in a Multiplayer game.
- Xenophobia
Kill 10 or more enemies at the same time with any weapon.
- Focused Mind
Defeat a Doorkeeper without taking any damage.
- Dreamkiller
Defeat a Dreamkiller without taking any damage.
- Suicidal Tendencies
Die 10 times to self-inflicted explosives fire in any Single Player mode.
- Delusions of Grandeur
Finish a Deathmatch game with the highest score (with at least 3 other players involved).
- Mind Guard
Return your team's flag at least 5 times in one CTF match.
- Mastermind
Conquer 50 brains in Conquest mode.
- Psycho Logical
Complete a Single Player game in Time Trial mode.
- Simple Jack
Complete a Single Player game in Single Weapon mode.