Here is the full list of all 49 Call of Cthulhu achievements. It takes around 12-15 hours to unlock all of the achievements on Windows.
Find 20 hidden items
Find occult items
Choose all the replies in R’lyehian
Piece together Margaret Wyckwood's memoirs
Never drink
Discover all the small blue bottles
Read all the books of unholy knowledge
Save Mitchell
Make the suspects talk by using a heavy hand
Push Irene Sanders to the limit
Use the globe to open the secret passage
Deliver liquor to the sailors
Be the plaything of an hallucination
Discover all the murals of the disappeared tribe
Refuse the ritual
Refuse to take part in the ritual
Invoke Cthulhu!
Successfully carry out the counter ritual
Chat with a vision
Open the sailor's chest in the whaling station
Enter the beast’s den
Kill 5 inhabitants who are being controlled
Kill or spare Bradley
Escape your fallen territory
Save Drake's life during the fight with the creature
Banish the creature for good
Accept the revelations
Lay your hands on Algernon Drake's treasure
Find Sarah Hawkins
Fall into Fuller's trap
Meet Algernon Drake and accept his help
Learn the secret of the Scylla
Heal all the patients
Read the Necronomicon
Banish the Dimensional Shambler
Banish the Dimensional Shambler using only one dagger
Accept to read an unholy book
Inspect 50 items
Meet Francis Sanders
Make a deal with a crazed inmate
Take part in the ritual in the caves
Fall into the sacrificial pit
Discover the mansion’s secret passage
Reach the level of Expert in a skill
Explore the memories of the Hawkins family
Convince the caretaker to help you
Get driven to the Hawkins Mansion
Fail a skill test
Accept the Sarah Hawkins case