Do this on Too Easy; it is way too hard on Easy (i.e. Hard). You start with only the Prisoner Prod, everything else has to be researched. I made sure to research either Industry or Food Replicator Level 1 before leaving Floor 1. The Neurostun Module should be your priority after getting Industry and Science Generator and Food Replicator.
If you see a Dust Box, prioritize getting it so you can bring extra dust to the next floor.
Characters
I started with Wes Davoun (starts with Operate) and Mizi Kurtiz (best solo room defender). Later I picked up Rosetta (Crystal runner) and Hikensha (strong fighter). For the most part, I had everyone but Mizi operate, saving up Industry and Food. For those who don't have Operate this required a Scope, Energy Bar, or Training Manual.
Setup
Each floor I try to open all doors immediately around the Crystal, and set up an Industry Generator and a Food Replicator. I like to have a Smoking Gun, Kip Cannon, Neurostun Module, and Tear Gas. If more than 4 minor module slots, I add more Kip Cannons. If less than 4, I drop the Tear Gas.
Progression
For the first 12 to 15 floors, you'll want to open all the doors if possible so you can save up Industry and Food, and ideally level everyone up to 15. By the time you reach Floor 18 you'll need to get to the exit as quickly as possible since you'll be low on light.