Are you in for a trip on the midnight isles for the most random conspiracy? Yes, okay. Good luck.
First: Have a party of friends with high perception/religion, you only get one shot to discover each place.
Second: Middle city, close to Ten Thousand Delights, you can find a group of demodands arguing around, kill them and loot the Demodand Leader, what you want is the Thanatonic Minor rune.
Third: Go back to the lower city, close to the elevator, go towards the bottom left corner of the map, its near the checks that allow you to go to middle city before intended, find the socket hidden behind the perception/religion, put the stone in, prepare yourself for a three wave battle, the enemies pack considerable power but a well buffed team should be able to send them back to the abyss( wait a minute...), open the socket, take the rune.
Fourth: Middle city, near the aasimar's house, go towards the top right corner of the map, by the side of the house you can find the second socket, another battle, more powerful tier of enemies, kill, take the rune back.
fifth: Upper city, go to the roof of Willodus' mansion, top center side of the map, get ready, Vavakia's will be present this time, clear the floor with their faces, make the blood rain and take the rune that is now totally empowered.
Sixth: Middle city, Harem of ardent dreams, there is a corridor near the Harem that almost looks like it will lead to nowhere, follow it until you are behind the building, last socket, prepare for the last battle.
This is tough, archers on the higher area, kineticists in the end of the room, Galaus (worst enemy ever, F*** that rain of blood that can be easily countered with a channel positive energy), during the fight, stringy demodands will spawn behind you, beware of attacking the kineticists as demodands can rob you of your weapons because of sticky skin (filthy bastards, go take a bath), kill everything that moves, dispel the leader to have a chance to hit, buff yourself with everything you got, you can always rest after.
Credit to ALEC for their
guide.