STORY and UNMISSABLE
You will get this trophy automatically after defeating Nemesis during your second encounter at the Clock Tower Plaza.
A basic strategy for this fight is to use the Grenade Launcher with the Mine Rounds (you'll find extra ammunition at the Plaza) and launch them in advance to the path you see Nemesis is going to take (either on the floor or on the walls). Once the Mine Rounds make an impact, take this moment to deal damage with your strongest weapons. If you don't have Mine Rounds, focus on Nemesis´s weakspots (head and chest) and keep your distance. Dodge in a timely manner and take advantage of any perfect dodge you might get to deal extra damage.
When Nemesis starts to run through the walls, try to attack him with any of the Grenade Launchers´s ammunition (Flame, Acid or Grenade) in order to make him fall to the ground and use this opportunity to deal some extra damage. After some hits, Nemesis will fall and you will get this trophy.