Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Beat depths without taking damage.
You became Lord of the Flies.
OMG!
Isaac now holds the D6!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
You are the best!!
Unlocked Challenge #11.
Unlocked a new boss!
Unlocked Challenge #19.
New boss in the caves!
They are waiting.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Beat caves without taking damage.
Donated 200 pennies to the shop.
Beat womb without taking damage.
Unlocked Challenge #8.
New boss in the basement!
Unlocked Challenge #9.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Built him out of meat cubes.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Lilith.
Complete the Corpse with Bethany.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete ??? with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
Complete the Corpse with Eden.
Kill 10 Battery Bums.
Complete Boss Rush with Bethany.
Complete the Corpse with Azazel.
Complete the Corpse with Cain.
Defeat all bosses in the Mausoleum.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Make a new friend!
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Greedier mode with Bethany.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Beat Greed mode with Bethany.
Beat the game in Hard mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.