Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
OMG!
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked Challenge #19.
New boss in the womb!
You are the best!!
Isaac now holds the D6!
They are waiting.
New boss in the caves!
New boss in the basement!
Donated 200 pennies to the shop.
Unlocked a new boss!
Donated 100 pennies to the shop.
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Beat caves without taking damage.
Unlocked another miniboss!
The game just got harder!
Beat depths without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #8.
You became Lord of the Flies.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the Corpse with the Lost.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
The other side is calling...
Complete the Cathedral with Jacob and Esau.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Complete Sheol with Bethany.
Beat the Void with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Get that song out of her head.
Complete the Corpse with Samson.
Kill 10 Battery Bums.
Complete the Dark Room with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
They will charge you up... for a small fee.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Complete the Corpse with Azazel.
Defeat all bosses in the Mausoleum.
Kids shouldn't believe in fortunes...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in Downpour.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Spend 40+ pennies in a single shop.
Make a new friend!
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.