Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Complete the game.
Acquire all 46 upgrades through Consumes.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Defeat all Field Ops teams.
Find all BlackBoxes.
Reach the highest point in the world.
10 or more kills using a single Bio-Bomb.
Complete FALL FROM GRACE.
Destroy 5 helicopters using Pack Leader.
20 or more kills with a single Hammerfist dive attack.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy 5 vehicles using a Finisher.
Consume 10 //BLACKNET targets.
Stealth hijack 5 tanks or APCs.
Acquire a Mutation in each of the 5 categories.
Weaponize 10 vehicles.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Stealth Consume 50 Blackwatch troopers.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Acquire 5 Mutations.
10 or more kills with a single Black Hole attack.
Destroy a Strike Team in 15 seconds or less.
Karate kick a helicopter.
Dismember a Brawler.
Complete a //BLACKNET operation.
Acquire a Prototype Power.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
5 consumes in 10 seconds or less.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.