The game itself is quite simple, and isn't complicated whatsoever, especially due to some new mechanics in the series introduced within this game. Nothing should be overly difficult, and if it is, you can always check to see which difficulty you're playing on. The biggest challenge in this game is micromanaging the in-game challenges alongside the side content and the actual achievement list this game comes with.
The story expects you to know the events of at least Saints Row: The Third to be familiar with the immediate characters, but there are fair blots of story from the first two Saints Row games laced within it as well. To experience this game to its fullest, you would do well to have played the three games prior to this one before starting, but that's naturally up to your discretion. It's also highly recommended that you watch The Matrix before playing, too.
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