Full list of all 99 The Binding of Isaac achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 52 achievements, and there are 2 DLC packs containing 47 achievements.
Complete Sheol with Eve
Complete Sheol with Cain
You defeated Gish!
Complete the full game with ???
Complete the full game with Judas
Complete the full game 10 times
Complete Sheol with Judas
Complete the full game 9 times
Complete the full game 8 times
Complete the full game 7 times
Complete Sheol with Isaac
Give mom a taste of her own medicine!
Complete the full game 6 times
Complete the full game with Maggy
Dirty needles... eww
Call death upon all of them!
Complete the full game 5 times
Complete the full game 4 times
stay out of moms things!
Complete the full game 3 times
Complete the womb with Eve
ive lost my head one too many times...
Complete the full game 2 times
Defeat all bosses in the depths
Complete the full game with Cain
You defeated Steven!
You defeated C.H.A.D.!
Collect 50+ pennies in one play through
Complete the full game
Complete the basement without taking damage
Destroy the 7 Sins!
mom needs her pills! donate blood.
i lost mine in the arcade...
Collect 7+ container hearts in one play through
kill mom...
Kids shouldnt play with matches...
Complete the Caves
Defeat all bosses in the caves
Make 2 deals with the devil in one play through
Kids shouldnt play with dead things...
i like to break things...
Find Krampus in Satans room for a gift!
Complete the basement
Defeat all bosses in the basement
you dont wanna know where this bean has been...
100% the game
Make a Super Meat Boy!
Complete the caves without taking damage
Complete the depths without taking damage
Complete the womb without taking damage
Complete Sheol with Maggy
Complete Sheol with ???
Complete the final chapter with Cain
Kill moms heart with Samson
Complete the final chapter with Isaac
Complete the final chapter with Samson
Complete the final chapter with ???
Complete Challenge 3
Complete Challenge 8
Complete Challenge 5
Complete Challenge 1
Complete Challenge 4
Complete Challenge 7
Complete Challenge 6
Complete Challenge 2
???
Kill mom but pass on 2 treasure room items
Complete the final chapter with Maggy
Complete the final chapter with Judas
Complete the final chapter with Eve
Kill Satan with Samson
Complete Challenge 9
Beat Mom in Hardmode
Beat Moms Heart in Hardmode
Beat Satan in Hardmode
Beat the boss in the Cathedral in Hardmode
Beat the Game in Hardmode!
Gain 7 Health upgrades from Eternal Hearts
Beat the game as Isaac in Hardmode
Beat the game as Cain in Hardmode
Beat the game as Magdalen in Hardmode
Beat the game as Judas in Hardmode
Beat the game as Samson in Hardmode
Beat the game as Eve in Hardmode
Beat the game as ??? in Hardmode, and good luck!
Beat the game as all characters in Hardmode.
100% the game and hardmode (get all the achievements)