Here is the full list of all 50 Leap of Fate achievements.
Playing Rasimov, activate the Immortal ability 6 times and finish the game with full health.
Finish the game in Hard mode with Rasimov.
View every fate in the game.
Complete 120 missions.
Unlock all of Rasimov's permanent upgrades.
Finish the game in Normal mode with Rasimov.
Equip each of the 23 glyphs.
Unlock all of Mukai's permanent upgrades.
Finish the game in Hard mode with Mukai.
Finish the game without using any glyph.
Playing Mukai, finish the game by entering every card of every level (not counting extra cards or the shortcut card)
Finish the game in Normal mode with Mukai.
Complete 72 missions.
In a single playthrough, purchase 20 items in shops.
Unlock all of Big Mo's permanent upgrades.
Survive a One-Shot Kill card in which you lost health.
Finish the game without opening a single locked chest or locked card.
Finish the game in Hard mode with Big Mo.
Have 15 health.
Finish the game without purchasing a single skill upgrade.
Kill 13 creatures with a single blow.
Playing Big Mo, finish the game without overheating once.
Finish the game in Normal mode with Big Mo.
Unlock all of Aeon's permanent upgrades.
In a single playthrough, upgrade 6 skills from each of the three skill trees, and equip a gold glyph.
Playing Aeon, finish the game by using Shadow Bolt to deal the killing blow on each of the guardians.
In a single combat, generate 60 reflected projectiles by shooting at a reflective-aura protected creature.
Upgrade the same glyph twice in a single playthrough.
In a single playthrough, reroll 3 shops, bypass 2 cards, and cast destiny runes once.
Kill 7,500 creatures.
Accept 30 combat modifiers.
Finish the game with at least 7 keys, 7 energy cells and 1,500 mana.
Finish the game in Hard mode with Aeon.
In a single playthrough, take no damage in a 3-skull combat card. Do this 10 times.
In level 4, be within the range of a doll head's swirl of minions for 20 seconds.
Survive the secret Cthulhu card in Hard mode
Complete 20 missions.
Finish the game in Normal mode with Aeon.
Clear a level with special kills only.
Complete level 5.
Clear every challenge type once.
Equip a gold glyph.
Play with an alternate outfit.
Defeat 1,000 creatures with special kills.
Complete level 4.
Complete level 3.
Complete level 2.
Complete 5 missions.
Use a Continue.
Complete level 1.