Here is the full list of all 121 The Madness of Little Emma achievements.
Get very unlucky
Kill Eidolon
Reach The Riddle
Kill Manless Face
Kill all bosses in episode 3
Kill Sinister Mask
Destroy a turnip
Kill a shopkeeper
Kill 4 Seasons
Kill Summer
Kill all bosses in episode 1
Kill Winter
Kill Spring
Kill Autumn
Kill all bosses in episode 2
Kill Entozoon
Unlock first ending
Kill Meat Bag
Buy 5 items in one playthrough
Unlock Amelia
Have only 1 heart container
Reach Misery
Kill Red Viper
Unlock Lucretia
Kill the fat man
Kill Liquid Sisters
Kill Mask
Unlock Elizabeth
Reach Undergrounds
Find Love Burrow
Kill Alice
Reach Den
Kill Green Viper
Kill a boss
Kill Haunt
Collect 5 health bonuses in one game
Die
Find a secret
Unlock second ending
Unlock third ending
Unlock final ending
Kill all bosses in episode 4
Kill April
Find everything
Find a red chest
Complete ending 4 with clean mind all the time
Get really insane!
Get very lucky
Unlock every other achievement
Complete episode 1 without collecting hearts and healing herbs
Complete episode 2 without collecting hearts and healing herbs
Complete episode 3 without collecting hearts and healing herbs
Complete episode 4 without collecting hearts and healing herbs
Kill Spirit
Find all Love Items
Unlock fifth ending
Unlock sixth ending
Kill Manless Face as Amelia
Unlock Marah
Unlock Chloe
Complete Arena as Emma
Complete Arena
Complete Arena as Lucretia
Complete Arena as Elizabeth
Complete Arena as Amelia
Complete Arena as Marah
Complete Arena as Chloe