Here is the full list of all 121 The Madness of Little Emma achievements.
Unlock Chloe
Complete Arena as Elizabeth
Complete Arena
Unlock final ending
Kill all bosses in episode 4
Kill Spirit
Unlock Marah
Unlock fifth ending
Kill April
Unlock third ending
Unlock second ending
Get very lucky
Kill all bosses in episode 2
Kill Entozoon
Unlock Elizabeth
Complete episode 2 without collecting hearts and healing herbs
Find a red chest
Have only 1 heart container
Unlock Lucretia
Get very unlucky
Kill all bosses in episode 3
Kill Sinister Mask
Kill Eidolon
Reach The Riddle
Buy 5 items in one playthrough
Kill Winter
Kill 4 Seasons
Kill Autumn
Destroy a turnip
Kill Summer
Kill Spring
Unlock first ending
Get really insane!
Collect 5 health bonuses in one game
Kill Meat Bag
Kill Manless Face
Find Love Burrow
Unlock Amelia
Reach Misery
Find a secret
Kill all bosses in episode 1
Kill Haunt
Kill Green Viper
Kill Alice
Kill Red Viper
Kill a boss
Reach Den
Die
Reach Undergrounds
Kill Liquid Sisters
Kill Mask
Kill the fat man
Find everything
Complete ending 4 with clean mind all the time
Unlock every other achievement
Complete episode 1 without collecting hearts and healing herbs
Complete episode 3 without collecting hearts and healing herbs
Complete episode 4 without collecting hearts and healing herbs
Kill a shopkeeper
Find all Love Items
Unlock sixth ending
Kill Manless Face as Amelia
Complete Arena as Emma
Complete Arena as Lucretia
Complete Arena as Amelia
Complete Arena as Marah
Complete Arena as Chloe