Here is the full list of all 25 The Enchanted Cave 2 achievements.
Complete a New Game +
Complete the magic section of the skill tree
Completely fill all sections of the museum
Craft 75 total potions
Save three people
Save two people
Completely fill one equipment section of the museum
Complete the crafting section of the skill tree
Defeat the final boss
Successfully escape the cave with an artifact
Complete the main game in a single run
Transmute an item
Defeat the sorcerer
Reach character level 25
Discover 10 secret areas
Defeat the Yeti
Save one person
Equip an artifact in every equipment slot
Complete the combat section of the skill tree
Craft 15 total potions
Completely clear one floor of all enemies and loot
Complete the Monster's Lair Challenge
Complete the Labyrinth Challenge
Complete Green Goo's Quest