Here is the full list of all 25 The Enchanted Cave 2 achievements.
Complete the magic section of the skill tree
Complete the crafting section of the skill tree
Completely fill all sections of the museum
Complete a New Game +
Complete the main game in a single run
Craft 75 total potions
Completely fill one equipment section of the museum
Defeat the final boss
Transmute an item
Reach character level 25
Defeat the sorcerer
Equip an artifact in every equipment slot
Defeat the Yeti
Save three people
Discover 10 secret areas
Complete the combat section of the skill tree
Craft 15 total potions
Save two people
Successfully escape the cave with an artifact
Save one person
Completely clear one floor of all enemies and loot
Complete the Monster's Lair Challenge
Complete the Labyrinth Challenge
Complete Green Goo's Quest