Here is the full list of all 25 The Enchanted Cave 2 achievements.
Completely fill all sections of the museum
Complete the main game in a single run
Complete a New Game +
Defeat the final boss
Complete the Monster's Lair Challenge
Complete Green Goo's Quest
Complete the Labyrinth Challenge
Completely fill one equipment section of the museum
Defeat the sorcerer
Complete the magic section of the skill tree
Complete the crafting section of the skill tree
Save three people
Craft 75 total potions
Reach character level 25
Transmute an item
Defeat the Yeti
Craft 15 total potions
Save two people
Discover 10 secret areas
Equip an artifact in every equipment slot
Complete the combat section of the skill tree
Save one person
Successfully escape the cave with an artifact
Completely clear one floor of all enemies and loot